“AstroMelanin” is non-toxic and does not cause side effects on other organs and systems of the body. The technology is environmentally friendly.

Studies of cell biomass and “AstroMelanin” strains 365 and 1–365 isolated from them according to GOST 28178–89 on a specific test object showed a complete absence of acute toxicity, which proves the safety of “AstroMelanin”. The study of the acute toxicity of AstroMelanin in the substance was also carried out according to the “mini-toxic” program on 120 male hybrid mice (CBA x C57B16j ) with two routes of administration - per os and intraperitoneally. As can be seen from the data obtained, in the per os variant (recommended route of administration), the estimated semi-lethal dose is 3200 mg/kg of live weight at the recommended doses for an adult of 10-15-20 mg 2-3 times a day.

Thus, the obtained results on the acute toxicity of astromelanin in the substance in mice allow us to recommend its further study under the "mini-toxic" program (leading researcher of the laboratory of toxicology L.M. Mikhailova).